Published in Science Advances, the findings could help lead to better treatment options for infections, chronic inflammatory diseases and some cancers in the future. It could also impact patients suffering from inflammatory cancers, such as those in the bowel, where there is too little cell death. This discovery could have implications for patients suffering from chronic inflammatory diseases driven by unregulated cell death, such as psoriasis and rhuematoid arthritis. (L-R) Dr Najoua Lalaoui, Dr Lin Liu and Professor The WEHI-led collaboration, involving researchers from Zürich University, the University of Melbourne, the Hudson Institute of Medical Research and Monash University found an enzyme known as tankyrase-1 uses a ‘sugar tag’ to prevent excessive cell death. But when uncontrolled, it can lead to harmful amounts of inflammation in otherwise healthy organs and tissue, which fuels inflammatory disease. Inflammatory cell death is an important part of the body’s immune response. The findings could lead to better treatment options for inflammatory-driven infections, viruses and cancers.Study reveals how an enzyme uses a ‘sugar tag’ to prevent excessive cell death.Australian-Swiss research discovers a new way to control the cell death process.The discovery offers another way to regulate the cell death process for inflammatory diseases like psoriasis and inflammatory bowel disease – conditions that occur due to excessive cell death in the body – and could also help in future to reduce the severity of viruses like COVID-19. A WEHI-led study has identified a new enzyme involved in controlling cell death, in findings that could lead to better treatment options for a range of inflammatory conditions, cancers and viruses.
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